Curcu-Complete is a patent pending, highly bioavailable curcuminoid formulation. This product contains a unique combination of three bioactive, health-promoting curcuminoids: curcumin, bisdemethoxy curcumin and demethoxy curcumin, along with turmeric oil. The three curcuminoids are the strongest, most protective and best researched constituents of the turmeric root. Naturally occurring turmeric root powder contains only 5-7% curcumin, while the blend in Curcu-Complete is concentrated to contain 95% curcuminoids, of which curcumin represents 70%.
The crystalline structure of curcumin renders it difficult to absorb in the GI tract. According to researchers, “The potential health benefits of curcumin are limited by its poor solubility, low absorption from the gut, rapid metabolism and rapid systemic elimination.”1 For this reason, Curcu-Complete is manufactured using an all-natural formulation that improves the absorption and delivery of curcumin. This process uses a proprietary blend of MCT oils, non-soy derived lecithin, and vitamin E, without the use of potentially harmful surfactants. This delivery technology increases the absorption rate and reduces the absorption time for nutrients and may allow for superior effects through lower dosages.
Non-Medical Ingredients:Gelatin, purified water, glycerine, annatto (softgel ingredients).
Adults: Take one softgel per day with a meal, or as directed by a health care practitioner.
Warnings: Consult a health care practitioner prior to use if you are pregnant or breastfeeding, if you are taking antiplatelet medication or blood thinners, or if you have gallstones, a bile duct obstruction, a stomach ulcer or excess stomach acid.
Curcu-Complete is unique in that it has been shown to increase tetrahydrocurcumin as well as curcumin, demethoxycurcumin and bisdemethoxycurcumin in plasma. Tetrahydrocurcumin is a major metabolite of curcumin and demonstrates remarkable antioxidant properties exceeding those of curcumin alone. Compared to reference products containing equal concentrations of curcuminoids, Curcu-Complete exhibited several-fold higher absorption, resulting in plasma levels of tetrahydrocurcumin that were nearly 30 times higher. Area under the curve (AUC) amounts for plasma levels of all three curcuminoids in this formula were significantly higher than for the reference products.
Excessive inflammation is a common risk factor for disease occurrence and progression. Inflammation may lead to joint tissue destruction, cancer, cardiovascular events, insulin resistance/diabetes and brain/liver/kidney degenerative diseases. Research shows curcumin helps support a healthy inflammatory response. It was shown to reduce both acute and chronic inflammation caused by physical injury, joint wear and tear (as in osteoarthritis), chronic infections or inadequate antioxidant protection. Curcumin was shown to be more effective than certain NSAIDs in reducing inflammation and pain associated with rheumatoid arthritis or postoperative trauma. It has a better cardiovascular safety prole than aspirin because, unlike aspirin, it does not inhibit the arterial protective factor prostacyclin.
An additional effect of lipoic acid’s antioxidant capacity is its role in binding free, redox-active metals that can induce oxidative damage. LA has been shown to bind copper, manganese, zinc, and lead; whereas DHLA is effective at binding copper, zinc, lead, mercury, cadmium and iron. Related to its role as a water- and lipid-soluble antioxidant, lipoic acid also serves as an important cofactor for mitochondrial enzymes involved in cellular metabolism and energy (ATP) production, specifically pyruvate dehydrogenase and α-ketoglutarate dehydrogenase.
Curcumin may benefit ulcer, proctitis inflammation of the rectum common in ulcerative colitis and Crohn’s disease and may reduce leaky gut syndrome. “We conclude that antiulcer activity of curcumin is primarily attributed to matrix metalloproteinases -9 inhibition, one of the major path-ways of ulcer healing.” “A pure curcumin preparation was administered in an open label study to five patients with ulcerative proctitis and five with Crohn's disease. All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates.”
Curcumin may lower total cholesterol, fibrinogen and platelet aggregation, while increasing HDL and decreasing lipid peroxidation. In one study, “The effect of curcumin administration in reducing the serum levels of cholesterol and lipid peroxides was studied in ten healthy human volunteers, receiving 500 mg of curcumin per day for 7 days. A significant decrease in the level of serum lipid peroxides (33%), increase in HDL Cholesterol (29%), and a decrease in total serum cholesterol (11.63%) were noted.” According to another study, “Our reviewed data show that, in human healthy subjects, the daily intake of 200 mg of the above extract results in a decrease in total blood lipid peroxides as well as in HDL and LDL-lipid peroxidation. This anti-atherogenic effect was accompanied by a curcuma antioxidant-induced normalization of the plasma levels of fibrinogen and of the apo B/apo A ratio, that may also decrease the cardiovascular risk.”
Curcumin pretreatment reduced brain damage following ischemia/stroke51 and from heavy alcohol intake. Curcumin reduced development and severity of Alzheimer’s disease in animal models by reducing plaque aggregation and plaque induced oxidative stress and was even capable of dissociating existing plaque. Its chelating ability for iron and copper ions is also believed to play a beneficial role in reducing the progression of the disease. “Initially, we reported the impact of non-steroidal anti-inflammatory drugs (NSAIDs), notably ibuprofen, which reduced amyloid accumulation, but suppressed few inflammatory markers and without reducing oxidative damage. Safety concerns with chronic NSAIDs led to a screen of alternative NSAIDs and identification of the phenolic anti-inflammatory/anti-oxidant compound curcumin, the yellow pigment in turmeric that we found targeted multiple AD pathogenic cascades. The dietary omega-3 fatty acid, docosahexaenoic acid (DHA), also limited amyloid, oxidative damage and synaptic and cognitive deceits in a transgenic mouse model. Both DHA and curcumin have favorable safety proles, epidemiology and efficacy, and may exert general anti-aging benefits (anti-cancer and cardioprotective.)”
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